Amyotrophic Lateral Sclerosis
ALS is a progressive neurodegenerative disease that robs people of the ability to move and leads them to lose their ability to speak — and eventually breathe.
For over a decade, Biogen has been committed to advancing ALS research to provide a deeper understanding of all forms of this devastating disease, which currently impacts an estimated 168,000 people worldwide.
By leveraging established scientific capabilities and embarking on strong R&D collaborations, we’re determined to follow the science to advance a comprehensive, multi-modality ALS portfolio that fosters our long-term leadership in this space.
In 2015 Jeremy received news that his uncle had passed away from ALS. It was the first time a person in his family had been diagnosed with this disease, and while Jeremy was understandably bereaved, he assumed it was an isolated incident. Unbeknownst to Jeremy, however, his uncle had suffered from a form of ALS caused by a genetic C9orf72 expansion mutation – meaning that both he and his entire family would be at risk of inheriting the gene causing the disease.
Noel recounts his journey with ALS, outlining the importance of awareness in the search for improved treatment options.
Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder. Symptoms include progressive muscle weakness, paralysis and respiratory complications. Learn more about how the disease progresses in adults.
Biogen conducts clinical trials in ALS related to the investigational therapies in our pipeline to evaluate the efficacy and safety of potential medicines.
Deciding to participate in a clinical trial requires careful consideration. In most cases, the therapies investigated in clinical trials are not yet approved by regulatory agencies like the U.S. Food and Drug Administration (FDA). The benefits and risks of taking the treatment are not completely known. By volunteering for a clinical trial, you are helping the medical community determine whether new treatments are safe and effective.
ALS impacts approximately 168,000 people worldwide. 1
Average life expectancy for people with ALS is three to five years from the time of symptom onset.2
Two percent of ALS cases are caused by mutations in the SOD1 gene. Life expectancy in SOD1-ALS varies widely, with some patients surviving less than a year. 3