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Biogen has pioneered the development of multiple sclerosis (MS) treatments for more than 25 years. We continue to innovate to advance MS treatment and improve outcomes for patients. Our research is focused on potentially transformative therapies, including the potential repair of the damage caused by MS. Our ongoing research into neurodegeneration and nerve repair will help pioneer new therapeutic solutions that may bring us closer to a cure for MS.
At the same time, we are working with leading academic institutions and MS treatment centers to advance better ways to diagnose, monitor and manage MS. We are also driving advances toward precision medicine by using new technologies to develop innovative programs and tools to better understand, measure and manage the treatment of MS. Together with our partners, we are working to enable doctors and patients to make more evidence-based, individualized treatment decisions with the goal of improving MS care.
Our innovative research collaborations merge technologies like biomarkers and wearable sensors with real-world data from routine care to generate standardized, high-quality data that may help drive personalized treatment.
We developed one of the world’s largest MS databases to investigate critical questions about this disease, including if there are potential predictors of MS progression, or if certain treatments used early enough may have potential long-term benefits for patients, such as delaying the need for walking aids and wheelchairs or slowing the deterioration of other critical functions.
The work we are doing today in MS is designed to expand our focus well-beyond treatment and is vital to helping us better understand this disease.
Therapies
Today, our industry-leading portfolio of medicines helps address the diverse needs people living with MS may have throughout their lives.
We have the most robust portfolio of MS therapies in the industry with four disease-modifying therapies and one symptomatic therapy; globally, more than one in three MS patients is currently treated with a Biogen product.
We are always working to further our understanding of MS and how to treat it. This includes applying human genetics to understand the basis of disease progression, investigating new approaches to repair damaged nerves in the central nervous system with the goal of improving pre-existing disability, and looking at ways of treating progressive forms of MS.
Below you’ll find our current investigational therapies in MS.
Investigational candidates in multiple sclerosis
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BIIB098 (diroximel fumarate)
Multiple sclerosis (MS)
Licensed from Alkermes.
MS causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.
How this investigational therapy could help:
Diroximel fumarate (DRF) is an investigational, next-generation, oral fumarate for the treatment of MS and is differentiated from the currently marketed TECFIDERA (dimethyl fumarate) based on its chemical structure. Upon oral administration, DRF is rapidly converted to its active metabolite monomethyl fumarate (MMF). If approved, DRF may potentially offer differentiated gastrointestinal tolerability profile and offer patients with relapsing forms of MS another treatment choice.
Opicinumab (anti-LINGO)
Multiple sclerosis (MS)
This disease causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.
How this investigational therapy could help:
LINGO-1 is a CNS specific-protein that is involved in the development of myelin. In patients with MS, LINGO-1 may inhibit myelin growth when it binds with its receptor. Data suggest that the antibody anti-LINGO-1 could block this process, potentially allowing for the re-myelination and restoration of nerve communication in MS patients.
BIIB061 (oral remyelination)
Multiple Sclerosis (MS)
MS causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.
How this investigational therapy could help:
BIIB061 is an oral small molecule that induces growth of the cells that make myelin potentially allowing for the re-myelination and restoration of nerve communication in MS patients.
BIIB091 (BTK inhibitor)
Multiple sclerosis (MS)
MS causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.
How this investigational therapy could help:
BIIB091 selectively inhibits Burton’s tyrosine kinase (BTK), a non-receptor tyrosine kinase that regulates the development and signaling of B cells and myeloid cells hypothesized to contribute to MS pathogenesis. In addition, BTK has been demonstrated to play a key role in the activation of another cell of the immune system, the Myeloid cells via another receptor of this cell (Fcγ receptor signaling (FcγRs)).
Biogen conducts clinical trials in MS related to the investigational therapies in our pipeline to evaluate the efficacy and safety as potential medicines.
Deciding to participate in a clinical trial requires careful consideration. In most cases, the therapies investigated in clinical trials are not yet approved by regulatory agencies like the U.S. Food and Drug Administration (FDA). The benefits and risks of taking the treatment are not completely known. By volunteering for a clinical trial, you are helping the medical community determine whether new treatments are safe and effective.
As part of our ongoing commitment to people living with MS, Biogen provides extra support through the Above MS™ program.
There are many benefits to joining the Above MS program. Members will get extra help from those who understand MS, including:
Specially tailored information from people who are living with relapsing MS, but are also experts in areas such as financial planning, cooking, exercise, and many other areas
One-on-one MS support over the phone
A community of peers
Information about Biogen treatment options and support services
Please keep in mind that a doctor is always the primary resource when it comes to MS and treatment.
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