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Committed to improving the lives of patients

We work to transform the lives of the patients we serve. Meeting their individual needs is what drives our science and provides our focus.

A Global Voyage: Oceans of Hope

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Oceans of Hope sails around the world to change the perception of possibility for multiple sclerosis patients.


The stories that inspire our science

Meet some of our patients and hear their stories in their own words

Craig
Journalist and Storyteller
"I hope by talking about what I’ve been through I can be an inspiration to the next generation."
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Melanie
Volunteer and Animal Lover
"I’ve done everything I wanted; I just had to be a little more creative. I want to give others hope that they can do it, too."
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Michelle
World Traveler and Executive Assistant
"I want people to know that you can do anything you want; you just have to figure out how."
Read more
Richard
General Contractor and Business Owner
"If helping others and sharing my story can make the transition to being a patient easier for just one person, I’ve done a good thing."
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Daniel
Musician and Swimmer
"Having hemophilia has taught me two major lessons by which I live: never waste time and never be afraid to seize an opportunity."
Read more
Kate
Volunteer and Small-Business Owner
"When I was first diagnosed, I was very worried that I would have to give up everything that I loved doing, and that I would be alone in a bubble with my MS. I felt isolated, and the uncertainty was huge."
Read more
Rosemarie
Swimmer and Volunteer
"Today I focus on what I call ‘the gifts’ MS brought me, like the chance to spend more time with my daughter when she was growing up."
Read more
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Extending our support in meaningful ways

We believe our therapies can be even more effective when backed by services that support patients emotionally, financially and medically.

Multiple sclerosis (MS) support

  • Multiple sclerosis (MS) support
  • Hemophilia support
  • Partnered therapy support
Multiple sclerosis (MS) support | 1-800-456-2255 AboveMS.com

Multiple sclerosis (MS) support

As part of our ongoing commitment to people living with multiple sclerosis (MS), Biogen provides extra support through the Above MS™ program.

There are many benefits to joining the Above MS program. Members will get extra help from those who understand MS, including:

  • Specially tailored information from people who are living with relapsing MS, but are also experts in areas such as financial planning, cooking, exercise, and many other areas
  • One-on-one MS support over the phone
  • A community of peers
  • Information about Biogen treatment options and support services
  • Access to Nurse Educators
  • Financial and insurance support if eligible

Join the Above MS program by calling:

1-800-456-2255
Monday – Friday, 8:30 a.m. – 8 p.m. ET
AboveMS.com

Please keep in mind that a doctor is always the primary resource when it comes to MS and treatment.

Hemophilia support

Hemophilia support

At Biogen, we have listened to the people affected by hemophilia and are providing comprehensive access and assistance programs shaped by community input. We are committed to enabling access to therapy; our goal is for no one to forgo treatment based on financial limitations or insurance status. We offer a variety of personalized assistance and resources through MyELOCTATE™ Services and MyALPROLIX™ Services.

Everyone who calls into MyELOCTATE or MyALPROLIX will talk to a coordinator who will provide dedicated, one-on-one assistance: someone who will work with the individual and tailor resources to help meet their needs. To support access to therapy, these highly trained coordinators will work directly with people with hemophilia, their loved ones, healthcare providers, pharmacies and home healthcare teams. For clinicians, the programs provide a range of professional support materials to facilitate the use of Biogen therapies for appropriate individuals.

Coordinators provide people with hemophilia and their families with:

  • Assistance on how to receive therapy or with monthly out-of-pocket costs
  • Support for continued access to treatment, including if they have a lapse in insurance coverage or have reached their cap
  • A better understanding of their insurance coverage options.

To learn more about these services, please call or visit:

MyELOCTATE – hemophilia A resources
1-855-MyELOCTATE (1-855-693-5628)
Monday–Friday, 8 a.m.–10 p.m. ET
ELOCTATE.com

MyALPROLIX - hemophilia B resources
1-855-MyALPROLIX (1-855-692-5776)
Monday–Friday, 8 a.m.–10 p.m. ET
ALPROLIX.com

Partnered therapy support

Partnered therapy support

RITUXAN® (rituximab) and GAZYVA® (obinutuzumab) patient support is managed by Genentech, a member of Roche Group.

RITUXAN support service

1-877-474-8892
Monday–Friday, 8 a.m.–11 p.m. ET; Saturday, 9 a.m.–1 p.m. ET
Rituxan.com

GAZYVA support service

1-877-218-3996
24 hours a day, 7 days a week
Gazyva.com

Multiple sclerosis (MS) support | 1-800-456-2255 AboveMS.com
Hemophilia support
Partnered therapy support

Dedicated to new discoveries

Our pipeline is more than a list of medicines in development. It reflects the work we do here every day to break new ground with science that makes a difference in the lives of patients.

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  • Daclizumab High-Yield Process

    Relapsing-remitting multiple sclerosis (MS)

    Developed in collaboration with AbbVie Biotherapeutics.

    This disease causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to the myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking.

    How this therapy could help:

    Patients who have relapsing-remitting MS experience attacks, or relapses, of neurologic impairment, followed by periods of partial or complete recovery. Daclizumab HYP is an antibody that binds to CD25, a receptor highly expressed in immune cells abnormally activated in MS. Binding Daclizumab HYP and CD25 may normalize immune cell activity, possibly preventing relapses and slowing the progress of the disease.

  • ISIS-SMNrx

    Spinal muscular atrophy (SMA)

    Developed in collaboration with Isis Pharmaceuticals.

    People with this rare, inherited genetic disease lack a protein called SMN that helps with muscle control. Children born with SMA have difficulty eating, often miss developmental milestones and experience muscle weakness and wasting in the legs, arms and torso. SMA can lead to death by respiratory failure at a young age.

    How this therapy could help:
    ISIS-SMNrx is thought to promote the production of functional SMN protein, potentially improving the motor function and life span of patients with SMA. 


    View enrolling Biogen-sponsored trials for SMA

  • Natalizumab

    Secondary progressive multiple sclerosis (SPMS)

    Currently approved as TYSABRI® for relapsing-remitting multiple sclerosis and Crohn’s disease. Please visit TYSABRI.com for prescribing and safety information.

    MS causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to the myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking.

    How this therapy could help:

    After a period of experiencing relapses (increased impairment) and remission (improved ability), many MS patients will eventually enter secondary-progressive MS (SPMS): steady progression of neurological damage. Natalizumab may help by potentially reducing the disability progression.

  • Obinutuzumab (GA101)

    Diffuse large B-cell lymphoma (DLBCL)

    Currently approved as GAZYVA® for chronic lymphocytic leukemia (CLL). Please visit GAZYVA.com for prescribing and safety information.

    DLBCL is a type of non-Hodgkin’s lymphoma (NHL), a cancer of the immune system. NHL involves white blood cells (known as lymphocytes). Under normal conditions, these cells help defend the body from disease. In people with NHL, too many abnormal white blood cells build up in the blood, bone marrow, spleen and/or lymph nodes. Most NHL occurs in white blood cells called B cells. Intermediate and high-grade, or fast-growing, tumors are called aggressive NHL. DLBCL is the most common type of aggressive NHL.

    How this therapy could help:

    Obinutuzumab is a type of antibody therapy that targets and attaches to the CD20 protein found on the surface of NHL cells. Once attached to the CD20 protein, Obinutuzumab works in two different ways:

    • By helping the immune system destroy cancer cells
    • By destroying cancer cells on its own


    We collaborate on obinutuzumab in the U.S. with Genentech, Inc., a wholly-owned member of the Roche Group. The Roche Group and its sub-licensees maintain sole responsibility for the development, manufacturing and commercialization of obinutuzumab.

  • Obinutuzumab (GA101)

    Indolent non-Hodgkin’s lymphoma, front-line and refractory

    Currently approved as GAZYVA® for chronic lymphocytic leukemia (CLL). Please visit GAZYVA.com for prescribing and safety information.

    Non-Hodgkin’s lymphoma, or NHL, is a type of cancer of the immune system. NHL involves white blood cells (known as lymphocytes). Under normal conditions, these cells help defend the body from disease. In people with NHL, too many abnormal white blood cells build up in the blood, bone marrow, spleen and/or lymph nodes. Most NHL occurs in white blood cells called B cells. Low-grade, or slow-growing, tumors are called indolent NHL. Many patients live with indolent NHL for many years.

    How this therapy could help:

    Obinutuzumab is a type of antibody therapy that targets and attaches to the CD20 protein found on the surface of NHL cells. Once attached to the CD20 protein, obinutuzumab works in two different ways:

    • By helping the immune system destroy cancer cells;
    • By destroying cancer cells on its own.


    We collaborate on obinutuzumab in the U.S. with Genentech, Inc., a wholly-owned member of the Roche Group. The Roche Group and its sub-licensees maintain sole responsibility for the development, manufacturing and commercialization of obinutuzumab.

  • Anti-LINGO-1 (BIIB033)

    Multiple sclerosis (MS)

    This disease causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.

    How this therapy could help:

    LINGO is a neurologic protein that is involved in the development of myelin. In patients with MS, LINGO may inhibit myelin growth when it binds with its normal receptor. Data suggest that the antibody anti-LINGO-1 could block this process, potentially allowing for the re-myelination and restoration of nerve communication in MS patients

  • Anti-TWEAK

    Lupus nephritis

    This kidney disorder is caused by systemic lupus erythematosus (SLE or lupus). SLE is a chronic inflammatory disease. It occurs when the body’s own immune system mistakenly attacks healthy tissue in skin, joints, kidneys, the brain and other organs. It is a difficult disease to diagnose because it resembles several other conditions.

    How this therapy could help:

    Scientists have linked TWEAK, an immune cell protein, to increased disease activity in lupus nephritis. When TWEAK binds to its normal receptor, inflammation can be the result. TWEAK binding to the anti-TWEAK antibody could block this process and potentially diminish inflammation.

  • BG00011 (STX-100)

    Idiopathic pulmonary fibrosis (IPF)

    Pulmonary fibrosis is a disease in which lung tissue becomes thickened and stiff due to scarring. The formation of scar tissue is called fibrosis. As the disease progresses, it becomes harder for the lungs to work properly and the body cannot get the oxygen it needs. This debilitating disease is almost always fatal.

    How this therapy could help:

    The TGF-beta brain cell pathway is involved in several fibrotic diseases. The BG00011 (STX-100) antibody may selectively block the TGF-beta pathway, and may slow the development of fibrosis in IPF patients.

  • BAN2401 (Humanized anti-amyloid beta mab)

    Alzheimer’s disease

    Developed in collaboration with Eisai Co., Ltd.

    The most common cause of dementia, Alzheimer’s disease is a brain disorder that leads to impairment of intellectual functions and social skills, resulting ultimately in significant disturbance of daily living activities. Dementia is caused by the destruction of cells in certain parts of the brain primarily involved in memory and mental function.

    How this therapy could help:

    The memory loss and functionality decline of Alzheimer’s disease have been linked to amyloid plaques, abnormal protein deposits that build up in the brain. BAN2401 is an antibody that binds to amyloid, which could reduce its presence in the brain and potentially slow the progress of the disease.

  • CNV1014802

    Trigeminal neuralgia (TGN)

    Acquired in acquisition of Convergence Pharmaceuticals

    Trigeminal neuralgia is an extremely painful condition usually involving one side of the face. Trigeminal neuralgia is characterized by sudden, brief, stabbing, recurrent episodes of pain which frequently occurs spontaneously but is also commonly evoked by trivial stimuli including washing, shaving, smoking, talking and/or brushing the teeth (trigger factors). The pain follows one or more branches of the trigeminal nerve, which provides nerve sensation from the mouth, face and the front of the scalp. The intensity of the pain and its unpredictability results in profound effects on the quality of life of patients.

    How this therapy could help:

    CNV1014802 is a novel state dependent small molecule sodium channel blocker that preferentially inhibits the Nav 1.7 ion channel, a therapeutic target implicated by genetics in human pain conditions. CNV1014802 is thought to penetrate the central nervous system and block Nav channels in a novel manner, and has the potential to provide a new and effective option for the treatment of trigeminal neuralgia.

  • E2609 (BACE1 inhibitor)

    Alzheimer's disease

    Developed in collaboration with Eisai Co., Ltd.

    The most common cause of dementia, Alzheimer’s disease is a brain disorder that leads to impairment of intellectual functions and social skills, resulting ultimately in significant disturbance of daily living activities. Dementia is caused by the destruction of cells in certain parts of the brain primarily involved in memory and mental function.

    How this therapy could help:

    The memory loss and functionality decline of Alzheimer’s disease have been linked to amyloid plaques, abnormal protein deposits that build up in the brain. E2609 is a small-molecule inhibitor of beta-secretase, a protein that cleaves enzyme 1 (BACE1). By inhibiting BACE1, E2609 blocks amyloid production, potentially slowing the progress of the disease.

  • Natalizumab

    Acute ischemic stroke

    Currently approved as TYSABRI® for relapsing-remitting multiple sclerosis and Crohn’s disease. Please visit TYSABRI.com for prescribing and safety information.

    It is estimated that nearly two million people in the United States and the European Union will have a stroke each year. Stroke is a leading cause of mortality and serious long-term disability. There is a substantial unmet medical need for new therapies that can improve outcomes in acute stroke. 

    How this therapy could help:

    Natalizumab is thought to reduce the inflammatory cells in the brain by blocking the lymphocytic infiltration, known to occur in the brain following stroke, which may reduce the extent of injury.

  • Aducanumab (BIIB037)

    Alzheimer’s disease

    The most common cause of dementia, Alzheimer’s disease is a brain disorder that leads to impairment of intellectual functions and social skills, resulting ultimately in significant disturbance of daily living activities. Dementia is caused by the destruction of cells in certain parts of the brain primarily involved in memory and mental function.

    How this therapy could help:
    The memory loss and functional decline of Alzheimer’s disease have been linked to amyloid plaques, abnormal protein deposits that build up in  the brain. BIIB037 is an antibody that binds to and may reduce amyloid plaques from the brain, potentially slowing the progress of the disease.


    More information about our aducanumab clinical trials

  • Anti-alpha Synuclein mAb (BIIB054)

    Parkinson's disease

    Parkinson's disease is a disorder of the central nervous system. People who have this disease experience tremors, slow movement, muscle stiffness, and impaired balance.  As these symptoms become progressively worse, patients have difficulty walking, talking, or completing other simple tasks.

    How this therapy could help:
    BIIB054 targets abnormal alpha Synuclein protein that is associated with the destruction of nerve cells. This progressive degeneration is the cause of Parkinson's disease.

  • Anti-BDCA2

    Systemic lupus erythematosus (SLE)

    This chronic inflammatory disease occurs when the body’s own immune system mistakenly attacks healthy tissue in skin, joints, kidneys, the brain and other organs. It is a difficult disease to diagnose because it resembles several other conditions.

    How this therapy could help:

    BDCA2 is a protein present in specific cells within the immune system. An antibody against BDCA2 can potentially interrupt production of interferons, inflammatory molecules that are increased in patients with SLE and contribute to disease activity. 

  • BIIB061 (Oral re-myelination)

    Multiple sclerosis (MS)

    This disease causes the body’s immune system to attack myelin, a protective sheath covering nerve fibers. Damage to myelin “short circuits” communication between the brain, spinal cord and other areas of the body, severely impairing such neurological functions as mobility, vision and thinking. Over time, the nerves themselves can become damaged permanently.

    How this therapy could help:

    Data suggest that BIIB061 treatment may lead to re-myelination, or the replacement of myelin on damaged nerve fibers.

  • Dapirolizumab Pegol (Anti-CD40L)

    Systemic lupus erythematosus (SLE)

    Developed in collaboration with UCB, Inc.

    This chronic inflammatory disease occurs when the body’s own immune system mistakenly attacks healthy tissue in skin, joints, kidneys, the brain and other organs. It is a difficult disease to diagnose because it resembles several other conditions.

    How this therapy could help:

    CD40L is a protein in B and T cells, which helps regulate the immune system. Dapirolizumab pegol (Anti-CD40L) is an antibody that blocks CD40L, potentially lessening disease activity in SLE patients.

  • ISIS-DMPKRX

    Myotonic dystrophy, type 1

    Developed in collaboration with Isis Pharmaceuticals

    People with this rare inherited genetic disease have a mutation in the DMPK gene. The mutation can affect multiple organ systems. People with the disease can suffer from weakness and slowed relaxation of contracted muscles (myotonia), as well as heart or breathing problems.

    How this therapy could help:

    ISIS-DMPKRX is anticipated to dampen the expression of the DMPK gene, slowing the disease progression and improving quality of life for patients with myotonic dystrophy, type 1.

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Biogen conducts clinical trials to assess new treatments and to investigate potential new uses and benefits for existing therapies.

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